Hyperfibrinolysis and acquired factor XIII deficiency in newly diagnosed pediatric malignancies.

نویسندگان

  • Verena Wiegering
  • Oliver Andres
  • Paul G Schlegel
  • Frank Deinlein
  • Matthias Eyrich
  • Alexander Sturm
چکیده

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Current understanding in diagnosis and management of factor XIII deficiency

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Background: Congenital factor XIII (FXIII) deficiency is one of the rarest bleeding disorders with a prevalence of one per 2 million in the general population. The disorder is accompanied by a high rate of life-threatening bleeding. Due to normal results of routine coagulation tests, diagnosis of the disorder is challenging, but molecular methods can be used for precise diagnosis. Direct mutati...

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Stroke, though rare in children is among the top 10 causes of death in childhood. Incidence of ischemic and hemorrhagic stroke is the same in children .We report a case of hemorrhagic stroke in a two year old girl who presented with a limp, inability to stand on the left leg and left hemiparesia. Her complaint began 10 days ago after a bout of left clonic seizure. She had been admitted to the h...

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Factor XIII deficiency is a bleeding disorder that its prevalence in the general population is about 1 in 2 million people around the world. In Iran, the high rate of consanguineous marriages lead to high rate of disorder with 473 factor XIII deficient patients that is about 12 times higher than the global Prevalence of disorder. The study, is a comprehensive review of all aspects of factor XII...

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عنوان ژورنال:
  • Haematologica

دوره 98 8  شماره 

صفحات  -

تاریخ انتشار 2013